We have a small consortium of bacteria that degrade polyamides very efficiently, and based on multi-omics data analysis we aim to identify the genes responsible for the polyamide degradation.

University of Kiel

3 to 6 months

35h / week

English B1

We have a small consortium of bacteria that degrade polyamides very efficiently. To date, hardly and enzymes exit that can do that. We have 3-6 bacteria sequenced from the consortium that need to be assembled. We additionally have the corresponding transcriptomes which need to be mapped onto the bacterial genomes. After differential gene expression analysis, we aim to identify the genes responsible for the polyamide degradation.

Tasks and duties entrusted to the student:
We have a small consortium of bacteria that degrade polyamides very efficiently. To date, hardly and enzymes exit that can do that. We have 3-6 bacteria sequenced from the consortium that need to be assembled. We additionally have the corresponding transcriptomes which need to be mapped onto the bacterial genomes. After differential gene expression analysis, we aim to identify the genes responsible for the polyamide degradation.

Skills to be acquired or developed:
Metagenomics and Transcriptomics data analysis of microbes that can be applied to a sample from any environment and not just restricted to the proposed project. A deeper understanding of computational biology with the possibility to develop your own pipelines

Dr. Cynthia Maria Chibani, cchibani@ifam.uni-kiel.de, +49 431 880-4337
Prof. Dr. Ruth Schmitz-Streit, rschmitz@ifam.uni-kiel.de, +49 431 880-4334