The secondment is framed within the study of sudden cardiac death (SCD) as the primary manifestation of inherited cardiomyopathies, a major challenge in contemporary cardiology. The research addresses both structural (DCM, ACM) and electrical disorders (Brugada, LQTS), which are characterized by significant clinical variability and incomplete penetrance.
During the secondment, the researcher will acquire a multidisciplinary set of skills designed to bridge the gap between bench research and clinical application.
Phenotypic Characterization: Gaining proficiency in the clinical manifestation of both structural (DCM, ACM) and primary electrical disorders (Brugada, LQTS).
Risk Stratification: Learning the current clinical protocols for predicting Sudden Cardiac Death (SCD) in families with high genetic susceptibility.
Scientific Analysis of ncRNAs: Biomarker Validation: Developing deep knowledge of the regulatory roles of non-coding RNAs (ncRNAs) as dynamic indicators of cardiac pathology.Different methologies, pros and cons. Functional Interpretation: Understanding how ncRNAs can be used as tools to decode complex molecular pathways beyond their role as simple diagnostic markers.
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.
